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Sepsis Awareness Month: HCA Healthcare expert shares his sepsis survival story

Sepsis Awareness Month: HCA Healthcare expert shares his sepsis survival story
Headshot of Dr. Jeffrey Guy
Dr. Jeffrey Guy, HCA Healthcare’s Vice President of Care Process Design

Dr. Jeffrey Guy has a special interest in the question of how to prevent sepsis. He survived a serious bout with it when he was 39 and doesn’t want anyone to go through what he did.

“I was a pretty fit guy. I ran marathons and did competitive kickboxing,” said Dr. Guy, who serves as vice president of care process design at HCA Healthcare. But sepsis took him away from the activities he enjoyed. “I spent six weeks in one of the intensive care units I was overseeing,” he said. Afterward, “It was a challenge for me to walk to the mailbox. It took me six to eight months to recover from that critical illness.”

What is sepsis?

Sepsis is a potentially life-threatening and life-altering system response to infection, Dr. Guy explained. “It causes an exaggerated immune response that can end up damaging key organs like the heart, lungs and kidneys, and potentially lead to death.”

He compared sepsis to an ember that sparks from a small campfire, suddenly threatening the whole forest. If it isn’t treated early, sepsis can progress into septic shock. Patients may need medications to support their blood pressure and a ventilator to breathe. “Their kidneys are at risk, and they could go into kidney failure and need dialysis,” said Dr. Guy. “These are the people who are at the highest risk of losing their lives.”

Sepsis is more common than one might think. It can happen in response to any kind of infection — a wound, an illness or even poor dental care. According to the Centers for Disease Control and Prevention (CDC), more than 1.7 million adults in the U.S. develop sepsis each year, and nearly 270,000 people die as a result. Sepsis is a leading cause of death in hospitals, but most infections that lead to sepsis start outside hospitals.

Infections caused by bacteria are most likely to cause sepsis. This includes infections in the lungs (pneumonia), urinary tract, skin or digestive tract. Viral infections, including the flu and COVID-19, can also lead to sepsis. In fact, the inflammatory cytokine storm that happens in severe COVID-19 is sepsis, Dr. Guy said. He added that viral sepsis can be especially hard to treat.

Did you know? HCA Healthcare’s Clinical Services Group (CSG) is comprised of approximately 300 physicians, nurses, pharmacists, data scientists, researchers and process improvement experts. CSG plays an integral role in delivering on our promise to improve more lives in more ways. Examples include a predictive algorithm to detect sepsis more quickly (SPOT), our research on elective deliveries to improve care for mothers and babies (39 Weeks), and our efforts to reduce healthcare-associated infections (REDUCE MRSA and ABATE).

Recognizing the signs

The key to successful treatment for sepsis is timely recognition and prompt use of antibiotics and IV fluids. “The chance of death goes up with every hour of delay,” said Dr. Guy.

The initial signs of sepsis, including fever, chills, rapid heartbeat, lower blood pressure and difficulty breathing, can be easy to confuse with other conditions. One of the most common symptoms is mental confusion, which can look like a stroke, a neurological condition or a diabetic event. This can make the condition difficult to recognize and diagnose.

Dr. Guy and his Care Process Design team partnered with HCA Healthcare’s Data Science and Information Technology teams to develop an award-winning way of recognizing sepsis early. It’s known as Sepsis Prediction and Optimization of Therapy (SPOT). SPOT continuously monitors vital signs, lab results, nursing reports and other data to detect often subtle changes in a patient’s condition and alert clinicians to signs of sepsis, as much as six hours earlier than previously, so they can take appropriate action. This system speeds up treatment and saves patients’ lives.

While these advancements are making a difference for patients, it’s important to know how to prevent sepsis, as it’s better to keep it from occurring than to treat it after symptoms appear.

Who’s at risk?

Anyone can develop sepsis from any infection. While there’s no way to predict who will develop sepsis and who won’t, the type of infection, its severity and how long it goes untreated can all play a role in the risk of sepsis.

Some people are at higher risk of developing sepsis, including those with weakened immune systems, cancer, or kidney or liver disease. Diabetes also raises the risk, especially if it is not managed well. People over 65 and children younger than one also have an increased risk of developing sepsis.

Dr. Guy pointed out that some medications can lead to a higher sepsis risk. Taking antibiotics too often or not finishing a course of antibiotics can make you more likely to get an infection that doesn’t respond to antibiotics. It’s also important to note that antibiotics don’t help with viruses and aren’t always needed for sinus infections or ear infections. Taking steroid medications, like prednisone or hydrocortisone, suppresses the immune system and may mask the early signs of infection, delaying treatment.

How to prevent sepsis

Remember: Sepsis can happen to anyone in response to any infection. To protect yourself and your loved ones, take these five critical steps:

  1. Stay up to date on vaccinations. This includes COVID-19, the flu, chickenpox, pneumonia and other vaccines recommended for your age and health conditions. Vaccines can prevent or limit the severity of these conditions and reduce their potential to lead to sepsis. “There’s clearly a survival advantage to being vaccinated,” said Dr. Guy.
  2. Manage chronic illnesses. Keeping blood pressure, diabetes, kidney disease and other conditions under control help keep your body strong and able to fight off infections. A healthy diet also feeds your immune system and helps it function properly. Seeing your doctor regularly and seeking care for chronic conditions can reduce your risk of sepsis as well.
  3. Practice good hygiene. Wash your hands using soap and water, or use hand sanitizer, especially after using the bathroom or blowing your nose, before eating, and after exposure to large groups or public places. Keep cuts clean and covered until they are healed.
  4. Know the warning signs of sepsis. These include high heart rate, low blood pressure, fever, chills, confusion, shortness of breath, extreme pain and clammy skin. Sometimes people feel faint or dizzy.
  5. Seek care early. Sepsis is a medical emergency. If you experience any warning signs, seek care immediately, especially if you have any of the risk factors described above.

Dr. Guy is proud of HCA Healthcare’s SPOT system and its track record of detecting and treating sepsis early and effectively. “Our efforts have resulted in a dramatic improvement in sepsis survival in our hospitals,” he said. “I’m so excited about the lives we’ve saved.”

Related article: Building on a legacy of innovation to deliver healthcare of the future

About HCA Healthcare

HCA Healthcare, one of the nation's leading providers of healthcare services, is comprised of 183 hospitals and more than 2,300 sites of care, in 20 states and the United Kingdom. Our more than 283,000 colleagues are connected by a single purpose — to give patients healthier tomorrows.

As an enterprise, we recognize the significant responsibility we have as a leading healthcare provider within each of the communities we serve, as well as the opportunity we have to improve the lives of the patients for whom we are entrusted to care. Through the compassion, knowledge and skill of our caregivers, and our ability to leverage our scale and innovative capabilities, HCA Healthcare is in a unique position to play a leading role in the transformation of care.

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