Triple negative breast cancer: Sarah Cannon discusses five key facts

Mother and daughter hugging and pressing their foreheads together

October is Breast Cancer Awareness Month, an annual campaign to raise awareness around breast cancer.  This year, we encourage you to learn something new about breast cancer.  Sarah Cannon, the Cancer Institute of HCA Healthcare, shines light on a type of breast cancer, triple negative breast cancer, below.  

Approximately every half hour, a woman in the U.S. is diagnosed with triple negative breast cancer (TNBC). What is TNBC? How is it different from other forms of breast cancer?

Dr. Stephanie Graff, Director of the Breast Cancer Program at Sarah Cannon Cancer Institute at HCA Healthcare Midwest Health and Associate Director of the Breast Cancer Research Program at Sarah Cannon Research Institute, shares five things you should know about TNBC.

5 key facts to know about TNBC.

1. Breast cancer is diagnosed based on the presence or absence of three receptors, which are drivers for the development and growth of breast cancer. These include estrogen receptor, progesterone receptor and HER2‐neu. Triple negative breast cancer is diagnosed when a woman’s pathology report indicates a negative result for all three.

Headshot of Stephanie Graff
Stephanie Graff, MD, Director of the Breast Cancer Program at Sarah Cannon Cancer Institute at HCA Healthcare Midwest Health and Associate Director of the Breast Cancer Research Program at Sarah Cannon Research Institute

2. About 10-20% of breast cancers are found to be triple negative.

3. TNBC occurs most frequently in women ages 40-50 (younger than the average age of diagnosis across other forms of the disease), African American women and Hispanic women, and those with BRCA1 mutations.

4. TNBC is more aggressive than other forms of breast cancer, making it more likely to spread to other parts of the body and more likely to recur early after treatment.

5. Significant advancements have been made in the development of hormonal therapies and HER2-targeted therapies, which work to interfere with drivers of breast cancer and slow the growth of cancer cells. Triple negative breast cancer is typically treated with a combination of therapies such as surgery, radiation therapy, and chemotherapy.

In 2019, atezeolizumab, a form of immunotherapy targeting triple negative breast cancers with PDL1 mutations, was the first approved targeted therapy in metastatic triple negative breast cancer. Sarah Cannon participated in the clinical trial that led to the approval. Ongoing clinical trials are being conducted for more effective therapies for TNBC. Learn about Sarah Cannon’s clinical trial offerings.

Read more about immunotherapy breakthroughs for TNBC here

“Triple negative breast cancer is a phrase that tells us what your cancer is not. Our hope is that some day in the near future we can determine what your cancer is,” said Dr. Stephanie Graff.

“Some of the most exciting advancements are being made in TNBC research. Ongoing research is aimed at identifying potentially hundreds of markers that may ‘turn on’ triple negative breast cancer and design drugs to target those pathways. I encourage patients with triple negative disease to ask if there are any clinical trials available to them.”

If you have questions about breast cancer treatment, you can speak to a registered nurse 24/7 through askSARAH at (844) 482-4812.

Sarah Cannon, the Cancer Institute of HCA Healthcare, offers integrated cancer services with convenient access to cutting-edge therapies for those facing cancer in communities across the United States and United Kingdom. Sarah Cannon’s cancer programs include individualized patient navigation provided by oncology-trained nurses, more than 1,100 stem cell transplants performed annually throughout the Sarah Cannon Blood Cancer Network, hundreds of clinical trials, and molecular profiling capabilities. Through its services, Sarah Cannon is providing state-of-the-art cancer care close to home for hundreds of thousands of patients, a number unmatched by any single cancer center.

About HCA Healthcare

HCA Healthcare, one of the nation's leading providers of healthcare services, is comprised of 183 hospitals and more than 2,300 sites of care, in 20 states and the United Kingdom. Our more than 283,000 colleagues are connected by a single purpose — to give patients healthier tomorrows.

As an enterprise, we recognize the significant responsibility we have as a leading healthcare provider within each of the communities we serve, as well as the opportunity we have to improve the lives of the patients for whom we are entrusted to care. Through the compassion, knowledge and skill of our caregivers, and our ability to leverage our scale and innovative capabilities, HCA Healthcare is in a unique position to play a leading role in the transformation of care.

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